Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Vaccine-induced immunity to HIV is a major research focus, but relevant correlates of protection remain controversial. Here, Pauthner et  al. study protection from hard-to-neutralize SHIVBG505 challenge after immunization with native-like BG505 Envelope trimers in nonhuman primates and identify neutralizing antibodies, but not T cell or ADCC activity, as correlates of protection.

Source: Immunity - December 11, 2018 Category: Allergy & Immunology Authors: Matthias G. Pauthner, Joseph P. Nkolola, Colin Havenar-Daughton, Ben Murrell, Samantha M. Reiss, Raiza Bastidas, J érémie Prévost, Rebecca Nedellec, Benjamin von Bredow, Peter Abbink, Christopher A. Cottrell, Daniel W. Kulp, Talar Tokatlian, Bartek Nog Tags: Article Source Type: research