GRADE approach to rate the certainty from a network meta-analysis: Addressing Incoherence

This article presents official guidance from the Grading of Recommendations Assessments, Development, and Evaluation (GRADE) working group on how to address incoherence when assessing the certainty in the evidence from network meta-analysis. Incoherence represents important differences between direct and indirect estimates that contribute to a network estimate. Bias due to limitations in study design or publication bias, indirectness, and intransitivity may be responsible for incoherence. Addressing incoherence requires a judgment regarding the importance of the impact on the network estimate.

Source: Journal of Clinical Epidemiology - December 5, 2018 Category: Epidemiology Authors: Romina Brignardello-Petersen, Reem A. Mustafa, Reed A.C. Siemieniuk, M. Hassan Murad, Thomas Agoritsas, Ariel Izcovich, Holger J. Sch ünemann, Gordon H. Guyatt, For the GRADE Working Group Tags: Original Article Source Type: research