Effects of Glucocorticoid-Induced Transcript 1 Gene Deficiency on Glucocorticoid Activation in Asthmatic Mice.

Conclusions: GLCCI1 deficiency in asthmatic mice inhibits the activation of GR and MKP-1 and leads to more obvious phosphorylation of p38 MAPK, leading to a decremental sensitivity to GCs. Trial Registration: ChiCTR.org.cn, ChiCTR-RCC-13003634; http://www.chictr.org.cn/showproj.aspx?proj=5926. PMID: 30511684 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30511684?dopt=Abstract

Source: Chinese Medical Journal - December 5, 2018 Category: General Medicine Authors: Hu CP, Xun QF, Li XZ, Hu XY, Qin L, He RX, Feng JT Tags: Chin Med J (Engl) Source Type: research