GSE106613 Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to other components of the m6A machinery

Contributors : Philip Knuckles ; Tina Lence ; Irmgard U Haussmann ; Dominik Jacob ; Nastasja Kreim ; Marco Biggiogera ; Marc Helm ; Marc B ühler ; Sarah H Carl ; Irene Masiello ; Tina Hares ; Rodrigo Villaseñor ; Daniel Hess ; Miguel A Andrade-Navarro ; Matthias Soller ; Jean-Yves RoignantSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusm6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly understood. Here we identified Zc3h13 as a novel interactor of m6A methyltransferase complex components in mouse. Like other components of this complex, Zc3h13 controls m6A levels.

Source: GEO: Gene Expression Omnibus - December 4, 2018 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research