GSE112858 Evolution of maternal and zygotic mRNA complements in the early Drosophila embryo

Contributors : Joel Atallah ; Susan E LottSeries Type : Expression profiling by high throughput sequencing ; Third-party reanalysisOrganism : Drosophila ananassae ; Drosophila erecta ; Drosophila mauritiana ; Drosophila melanogaster ; Drosophila miranda ; Drosophila mojavensis ; Drosophila persimilis ; Drosophila pseudoobscura ; Drosophila santomea ; Drosophila sechellia ; Drosophila simulans ; Drosophila virilis ; Drosophila willistoni ; Drosophila yakubaThe earliest stage of animal development is controlled by maternally deposited mRNA transcripts and proteins. Once the zygote is able to transcribe its own genome, maternal transcripts are degraded, in a tightly regulated process known as the maternal to zygotic transition (MZT). While this process has been well-studied within model species, we have little knowledge of how the pools of maternal and zygotic transcripts evolve. To characterize the evolutionary dynamics and functional constraints on the timing of early embryonic expression, we created a transcriptomic dataset for 14 Drosophila species spanning over 50 million years of evolution, at developmental stages before and after the MZT, and compared our results with a previously published Aedes aegypti developmental time course. We found deep conservation over 250 million years of a core set of genes transcribed only by the zygote. This select group is highly enriched in transcription factors that play critical roles in early development. However, we also identify a su...

Source: GEO: Gene Expression Omnibus - December 4, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Third-party reanalysis Drosophila ananassae Drosophila erecta Drosophila mauritiana Drosophila melanogaster Drosophila miranda Drosophila mojavensis Drosophila persimilis Drosophila pseu Source Type: research