Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies

Immunoglobulin E (IgE)-mediated food allergy is a growing problem with no curative therapy.1 Oral immunotherapy (OIT) has shown promise, but its utility is limited by reactions during treatment and a lack of sustained protection after therapy. Immunoglobulin E antibodies trigger hypersensitivity reactions to foods. Their effects, mediated by the high-affinity Immunoglobulin E receptor (Fc εRI) on mast cells and basophils, can be countered by IgG antibodies of shared specificity signaling via the inhibitory Fc receptor, FcγRIIb.

Source: Annals of Allergy, Asthma and Immunology - November 4, 2018 Category: Allergy & Immunology Authors: Amanda J. Stranks, Samantha C. Minnicozzi, Samuel J. Miller, Oliver T. Burton, Stephanie L. Logsdon, Jonathan M. Spergel, Kari C. Nadeau, Jacqueline A. Pongracic, Dale T. Umetsu, Rima Rachid, Andrew J. MacGinnitie, Lynda C. Schneider, Hans C. Oettgen Tags: Letters Source Type: research