Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans [Research Papers]

Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.

Source: Genes and Development - December 3, 2018 Category: Genetics & Stem Cells Authors: Son, H. G., Seo, K., Seo, M., Park, S., Ham, S., An, S. W. A., Choi, E.-S., Lee, Y., Baek, H., Kim, E., Ryu, Y., Ha, C. M., Hsu, A.-L., Roh, T.-Y., Jang, S. K., Lee, S.-J. V. Tags: Research Papers Source Type: research