The Bicuspid Condition of the Aortic Valve Does Not Alter the Incidence of Accessory Coronary Artery Ostia in Syrian Hamsters (Mesocricetus auratus)

Publication date: January 2019Source: Journal of Comparative Pathology, Volume 166Author(s): M.C. Fernández, M.T. Soto-Navarrete, A.C. Durán, V. Sans-Coma, B. FernándezSummaryIn man and Syrian hamsters (Mesocricetus auratus), the prevalence of anomalies in the origin of the coronary arteries is significantly higher in individuals with bicuspid than with normal aortic valves. In hamsters, the incidence of accessory ostia is similar in individuals with normal and anomalous coronary arteries, all of them possessing a normal (tricuspid) aortic valve. In order to evaluate whether or not the presence of bicuspid aortic valves alters the incidence of accessory ostia, 1,050 hearts from hamsters with bicuspid valves were examined. In 594 of them the coronary arteries were normal. The remaining 456 hearts showed coronary artery anomalies characterized by the absence of any artery arising from the left side of the valve. The incidence of accessory ostia was 3.9% in hamsters with normal coronary arteries and 2.2% in those with anomalous coronary patterns. Overall, 3.1% of the accessory ostia were associated with a septal artery and another 0.2% with a conal artery. These data referring to the bicuspid valves were compared with those already published on normal valves. The results of statistical analyses showed that having a bicuspid aortic valve does not alter the incidence of accessory coronary ostia. In the set of tricuspid and bicuspid valves, the incidence of accessory ostia was s...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research