Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.
Curr Opin Microbiol. 2018 Nov 24;46:116-122
Authors: Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM
Abstract
Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
PMID: 30481613 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - November 24, 2018 Category: Microbiology Authors: Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM Tags: Curr Opin Microbiol Source Type: research