Retrospective Analysis of Whole-Body Magnetic Resonance Imaging of Bone Manifestations in Long-Term Treated Patients with Gaucher Disease Type 1

Conclusion This retrospective study supported the ongoing clinical value of enzyme replacement therapy with alglucerase/imiglucerase, as WB-MRI-based scores stayed constant or slightly improved even after long-term treatment. Secondary complications were only observed in the late treatment group. Our results suggest that “early initiation” of enzyme replacement therapy may protect the bone. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Klinische Padiatrie - November 27, 2018 Category: Pediatrics Authors: Lollert, Andr é Laudemann, Katharina Mengel, Eugen Hoffmann, Christian Moos, Larissa Reinke, J örg Brixius-Huth, Miriam Hennermann, Julia B. D über, Christoph Staatz, Gundula Tags: Original Article Source Type: research