Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes

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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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PMID: 32463633 [PubMed - as supplied by publisher]
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
A fair amount of effort is presently put towards the exploration of supplements derived from vitamin B3 compounds (nicotinamide, niacin, nicotinamide riboside) that act as precursors to enable the manufacture of nicotinamide adenine dinucleotide (NAD). NAD is an important component in mitochondrial activity, and levels decline with age. Some portion of the loss of mitochondrial function, implicated in the progression of many age-related conditions, is due to NAD insufficiency. There is a rich history of the use of high doses of vitamin B3 as an intervention, most of it predating modern understanding of the role of NAD in m...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Regional efforts to control the spread of COVID-19 have so far proven successful. Image Credit: Pacific CommunityBy William W. EllisTORONTO, May 29 2020 (IPS) By now, the impact of COVID19 on our daily lives has been well documented, especially in advanced economies. Anxiety about the future continues to grow everywhere. Much of the corporate news coverage we consume has focused on the toll this pandemic will take on mainland countries. Often neglected, however, is the unique position Pacific Island States find themselves in. Globally, there are close to 6 million confirmed cases of COVID19. According to the Pacific Commu...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Climate Change Economy & Trade Featured Financial Crisis Global Headlines Health Humanitarian Emergencies Labour Multimedia Podcast TerraViva United Nations Secretariat of the Pacific Community (SPC) Source Type: news
TYPE 2 diabetes is a condition which is greatly affected by blood sugar levels. When a person's blood sugar levels rise, unusual and sometimes dangerous effects ensue. Feeling this way most of the time could mean your blood sugar is abnormally high.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Contributors : Wouter Eilers ; David Chambers ; Mark Cleasby ; Keith FosterSeries Type : Expression profiling by arrayOrganism : Mus musculusMyostatin (GDF8) is a member of the TGF-beta family of proteins which is predominantly expressed in skeletal muscle and acts as a negative regulator of muscle mass. Inhibition of myostatin leads to muscle hypertrophy and has been shown to mitigate insulin resistance in mouse models of type 2 diabetes, although the mechanisms underlying this effect are unclear. We found that myostatin inhibition by AAV-mediated overexpression of the myostatin propeptide improves skeletal muscle insulin...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 28 May 2020Source: Life SciencesAuthor(s): Sajad Jeddi, Sevda Gheibi, Khosrow Kashfi, Mattias Carlström, Asghar Ghasemi
Source: Life Sciences - Category: Biology Source Type: research
Abstract An Uncommon Cause of Arterial Hypertension Abstract. A 54-year-old patient was suffering from arterial hypertension, which was not treated sufficiently despite an antihypertensive therapy with three different types of drugs. In addition, the patient complained an increase in weight of ten kilos during the last year and a new onset of diabetes mellitus type 2. Investigations as to secondary forms of hypertension by MRI revealed an adrenal tumor with a diameter of approx. 6 cm suspect for an adrenal carcinoma. An ACTH-independent cushing syndrome was diagnosed by 24-hour urines collection, 1-mg dexamethason...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
This article summarizes what we know about the effect of metabolic surgery on the complications of diabetes, poses some unanswered questions, and suggests how we could answer them.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study compared the insulin lispro pharmacokinetics and glucodynamics, safety and tolerability of URLi and Humalog® after a single subcutaneous dose in patients with type 2 diabetes mellitus (T2DM).MethodsThis was a phase I, randomised, two-period, two-treatment, double-blind, crossover study in 38 patients with T2DM. At each dosing visit, patients received either 15 units of URLi or Humalog, followed by a 10  h automated euglycaemic clamp procedure. Serum insulin lispro and blood glucose were measured.ResultsInsulin lispro appeared in the serum 5  min faster (p 
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
DiscussionThe results of this trial will provide information about the effectiveness of the NUCOD program in improving clinical outcomes for diabetes and prediabetes individuals, and implementation outcomes for the organization. The continuum of care model can be used for the prevention and management of diabetes and other noncommunicable diseases within and beyond Nepal with similar context.Trial registrationClinicalTrials.gov,NCT04131257. Registered on 18 October 2019.
Source: Trials - Category: Research Source Type: clinical trials
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