CDC: U.S. Prevalence of ALS Was 5.2 Per 100,000 in 2015

MONDAY, Nov. 26, 2018 -- In 2015, the prevalence of amyotrophic lateral sclerosis (ALS) in the United States was 5.2 per 100,000 population, with 16,583 cases identified, according to research published in the Nov. 23 issue of the U.S. Centers for...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 23 May 2019Source: NeuroscienceAuthor(s): Lina Yan, Weijing Qi, Yaling Liu, Fuling Zhou, Yafei Wang, Lin Bai, Xiaomeng Zhou, Can Sun, Xiangyu Nie, Shiru Duan, Jina Ran, Juan Chen, Yingxiao Ji, Yakun Liu, Zhongyao Li, Yuanyuan Li, Qingxin WangAbstractAs an adult-onset neurodegenerative disease, amyotrophic lateral sclerosis (ALS) results in progressive muscular atrophy and paralysis. However, the mechanism of ALS has not yet been elucidated, and no cure has been found. Research has revealed that a mutation of the Cu/Zn superoxide dismutase (SOD1) gene is linked to familial ALS and that pot...
Source: Neuroscience - Category: Neuroscience Source Type: research
Conclusion: Our results do not support the causal role of genetically increased or decreased BMI on the risk of ALS.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
(Sanford Burnham Prebys Medical Discovery Institute) New research on amyotrophic lateral sclerosis (AML) has revealed that a protein called membralin plays a key role in the disease process. The study, published in Journal of Clinical Investigation, suggests that membralin-boosting gene therapy is a potential therapeutic direction to treat this often deadly disease.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
ConclusionThese findings collectively suggested that initial symptoms influenced phenotypes in SCA3 and that neurodegeneration in different parts of brain may induce different disease severity in SCA3.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: Overall, and even though we must account for the limitations of the indirect methods and models used for prevalence estimation, we probably have a very high ALS/MND prevalence in Portugal. It would be important to create registries, particularly in rare diseases, for better organization and distribution of healthcare services and resources, particularly at the level of ventilatory support.Neuroepidemiology
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based me...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Conclusion: This study provides evidence that not all ALS patients show contiguous clinical or electrophysiological spread patterns. The electrophysiological spread pattern can affect the functional staging in ALS patients. Keywords:Amyotrophic lateral sclerosis, prion-like mechanism, electrophysiology, spread pattern
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degenerative disease in adults and has also been proven to be a type of conformational disease associated with protein misfolding and dysfunction. To date, more than 150 distinct genes have been found to be associated with ALS, among which Superoxide Dismutase 1 (SOD1) is the first and the most extensively studied gene. It has been well established that SOD1 mutants-mediated toxicity is caused by a gain-of-function rather than the loss of the detoxifying activity of SOD1. Compared with the clear autosomal dominant inheritance of SOD1 mutants in ALS, the po...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Abstract Microglia are resident immune cells that act as the first active defence in the central nervous system. These cells constantly monitor the tissue microenvironment and rapidly react in response to hypoxia, infection and injuries. Hypoxia in the brain has been detected in several neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease and Huntington's disease. Hypoxic conditions activate microglia cells towards M1 phenotype resulting in oxidative stress and the release of pro-inflammatory cytokines. Recently, we have demonstrated that oxidative stress indu...
Source: Archives of Biochemistry and Biophysics - Category: Biochemistry Authors: Tags: Arch Biochem Biophys Source Type: research
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