CCR10+ ILC2s with ILC1 ‐like properties exhibit a protective function in severe allergic asthma

ConclusionsFrequencies of circulating CCR10+ ILC2s and CCL27 plasma concentrations represent candidate markers of asthma severity. The characterization of CCR10+ ILC2s in human samples and in mouse asthma models suggests that these cells downregulate allergic inflammation through IFN ‐γ production.This article is protected by copyright. All rights reserved.

Source: Allergy - November 26, 2018 Category: Allergy & Immunology Authors: Chlo é Beuraud, Vincent Lombardi, Sonia Luce, Stéphane Horiot, Emmanuel Naline, Catherine Neukirch, Sabi Airouche, Thibaut Perchet, Rachel Golub, Philippe Devillier, Sylvie Chollet‐Martin, Véronique Baron‐Bodo, Emmanuel Nony, Michel Au Tags: Original Article: Experimental Allergy and Immunology Source Type: research