Adversarial Domain Adaptation for Classification of Prostate Histopathology Whole-Slide Images.

Adversarial Domain Adaptation for Classification of Prostate Histopathology Whole-Slide Images. Med Image Comput Comput Assist Interv. 2018 Sep;11071:201-209 Authors: Ren J, Hacihaliloglu I, Singer EA, Foran DJ, Qi X Abstract Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances because of different tissue preparation and staining procedures, thus the predictable model learned from one domain may not be applicable to a new domain directly. Here we propose to adopt unsupervised domain adaptation to transfer the discriminative knowledge obtained from the source domain to the target domain with-out requiring labeling of images at the target domain. The adaptation is achieved through adversarial training to find an invariant feature space along with the proposed Siamese architecture on the target domain to add a regularization that is appropriate for the whole-slide images. We validate the method on two prostate cancer datasets and obtain significant classification improvement of Gleason scores as compared with the baseline models. PMID: 30465047 [PubMed - in process]
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research