Gout and CKD: A Common, Complicated Combination

What are the dos and don'ts when treating gout patients with chronic kidney disease? Take our 4-question quiz to find out.
Source: ConsultantLive - Category: Internal Medicine Authors: Source Type: news

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Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by UMOD gene mutation (ADTKD-UMOD) is rare in children, characterized by hyperuricemia, gout, and progressive chronic kidney disease. It usually...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Case report Source Type: research
ConclusionWe firstly reported skeletal deformity (fourth metatarsal microsomia), ovarian teratoma, and congenital ventricular septal defect as new phenotypes ofPAX2‐related disorder which enlarged the phenotypic spectrum. Gout was firstly reported as the onset symptom ofPAX2‐related disorder. The diagnosis ofPAX2‐related disorder should be considered without family history due to a much higher percentage ofDe novo mutations.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractBackground/objectiveNeck circumference (NC) is associated with metabolic abnormalities, independent of other obesity indices. However, data are limited regarding the potential relation between NC and serum uric acid (UA) concentrations. Therefore, we evaluated the cross-sectional association between NC and UA concentration, and odds of having hyperuricemia in a community-based cohort.Subjects and methodsThe current study included 87,782 participants (16,317 women and 71,465 men, 52.2  ± 14.1 y) of the Kailuan Study. NC and UA concentration were measured in 2014. We used generalized linear ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Shrikant R. Mulay1,2†, Martin Herrmann3†, Rostyslav Bilyy3,4†, Alexander Gabibov5† and Hans-Joachim Anders1*† 1Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany 2Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India 3Department of Internal Medicine 3, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany 4Department of Cytology Histology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Background/Aims: The safety and efficacy of febuxostat in patients with stage 4-5 chronic kidney disease (CKD) are still unclear owing to a lack of studies in these patients. Therefore, we aimed to evaluate the effect of febuxostat on renal function, general safety, and efficacy in gout patients with stage 4-5 CKD. Methods: Among 739 patients who had been administered febuxostat from May 2012 to December 2016 at a single hospital in Korea, 370 patients who had been monitored for 1 year were analyzed. Serum uric acid levels and estimated glomerular filtration rate (eGFR) of patients with gouty arthrit...
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
AbstractThere are many herbal products which are accessible to patients, and they may provide with many health benefits. Nevertheless, some of these supplements can lead to  significant morbidity as they can also have important side effects and impact patient’s organ systems. In this case report, we present a patient with chronic kidney disease secondary to type II diabetes mellitus who develops acute kidney injury and metabolic disturbances secondary to consuming b lack cherry concentrate as a mean to self-manage his gout flare. The most likely mechanism of injury was cyclooxygenase inhibition by anthocyanins, ...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Abstract Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout its...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
What is the relationship between gout and chronic kidney disease, and what role could urate-lowering therapy play in the development of CKD in these patients?Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
ConclusionsEvidence from our series of causal inference approaches using genetics does not support a causal effect of SU level on eGFR level or CKD risk. Reducing SU levels is unlikely to reduce the risk of CKD development.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
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