Isatin ‐SO3H coated on amino propyl modified magnetic nanoparticles (Fe3O4@APTES@isatin‐SO3H) as a recyclable magnetic nanoparticle for the simple and rapid synthesis of pyrano[2,3‐d] pyrimidines derivatives

Eco ‐friendly synthesis of pyrano[2,3‐d]pyrimidinone derivatives catalyzed isatin‐SO3H coated on amino propyl modified magneticnanoparticles in H2O:EtOH (1:1) is reported. Isatin ‐SO3H coated on amino propyl modified magnetic nanoparticles (Fe3O4@APTES@isatin ‐SO3H) is found to be a novel, efficient, and reusable magnetic nanocatalyst, and characterized by FT ‐IR, SEM, TEM, XRD, EDX, VSM, and TGA analysis. The magnetic nanocatalyst demonstrated outstanding performance in synthesis of pyrano[2,3‐d] pyrimidines derivativesvia one ‐pot three‐component reaction of various aromatic aldehydes 1, malononitrile 2, and barbituric acid 3 under reflux conditions in mixture of H2O:EtOH (1:1) as solvent. Easy workup procedure, short reaction time, high yield, simple preparation and easy recovery of the catalyst, mild reaction conditions are some advantages of this work.

Source: Applied Organometallic Chemistry - November 13, 2018 Category: Chemistry Authors: Sami Sajjadifar, Zohreh Gheisarzadeh Tags: FULL PAPER Source Type: research