Role of leucine zipper-like motifs in the oligomerization of Pseudomonas putida phasins

ConclusionsThese results indicate that coiled-coil motifs are essential for phasin interactions. Correct oligomerization requires the formation of a stable hydrophobic interface between both phasins.General Significance.Our findings elucidate the oligomerization motif of PhaF and PhaI. This motif is present in most phasins from PHA-accumulating bacteria and offers a potentially important target for modulating the PHA granules stability.Graphical abstract

Source: Biochimica et Biophysica Acta (BBA) General Subjects - November 11, 2018 Category: Biochemistry Source Type: research