Calcified Nodules Linked to AMD Progression Calcified Nodules Linked to AMD Progression

Calcified nodules in the retinas of patients with age-related macular degeneration are linked to the progression to advanced stage disease, a study has shown.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ophthalmology News Source Type: news

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Conclusions: CRISPR-mediated base editing can be used to facilitate a permanent and stably inherited cytosine-to-thymine nucleotide correction of the rs1061170 SNP in the CFH gene with minimal off-target effects. PMID: 30996586 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
Condition:   Dry AMD Interventions:   Other: Macuprev Group;   Other: Placebo Group Sponsor:   Fondazione G.B. Bietti, IRCCS Completed
Source: - Category: Research Source Type: clinical trials
Statement and supplementary statement from the BVA, the DOG, and the RG on laser treatment of drusen in age-related macular degeneration (AMD) : August 2017, update October 2018. Ophthalmologe. 2019 Apr 17;: Authors: Professional Association of German Ophthalmologists (Berufsverband der Augenärzte Deutschlands e. V., BVA), German Society of Ophthalmology (Deutsche Ophthalmologische Gesellschaft, DOG), German Retina Society (Retinologische Gesellschaft e. V., RG) PMID: 30997527 [PubMed - as supplied by publisher]
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
A hidden footprint: embryological origins of age related macular degeneration, Published online: 17 April 2019; doi:10.1038/s41433-019-0444-9A hidden footprint: embryological origins of age related macular degeneration
Source: Eye - Category: Opthalmology Authors: Source Type: research
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we characterized the retinas ofSphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured M üller glia for their response to S1P. We found that S1P plays an important role in retinal and retinal pigment epithelial (RPE) structural integrity in aging mice. Ultrastructural analysis ofSphk1 KO mouse retinas aged to 15  months or raised with moderate light stress revealed a degenerated outer limiting membrane (OLM). This membrane is formed by adherens junctions between neighboring Müller glia and photoreceptor cells. We also show thatSphk1 KO mice have reduced...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
In this study, the multivariate linear mixed model (LMM) was used to calculate the P-value to determine interesting SNPs at each time point using GEMMA software v0.97 (Zhou and Stephens, 2014). Growth data from both untreated and vancomycin-treated group formed the bivariate phenotype, which differs hugely from the univariate phenotype. Therefore, LMM developed for univariate phenotype cannot be applied to analyze correlated phenotype directly; methods allowing LMM algorithm specific to multivariate and correlated phenotype [multivariate LMMs (mvLMMs)] are in urgent need. GEMMA software could extend a standard LMM to mvLMM...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Basel, April 15, 2019 - Novartis announced that the US Food and Drug Administration (FDA) accepted the company's Biologics License Application (BLA) for brolucizumab (RTH258) for the treatment of wet age-related macular degeneration (AMD), also...
Source: - New Drug Applications - Category: Drugs & Pharmacology Source Type: news
Authors: Woo SJ, Cho GE, Cho JH Abstract PURPOSE: To investigate the short-term efficacy and safety of ranibizumab in the routine clinical setting in patients with neovascular age-related macular degeneration and to analyze the associated factors for visual outcome. METHODS: This was a post-hoc analysis of a ranibizumab regulatory post-marketing surveillance study in which 4,136 patients were enrolled and followed for 12 weeks. Change in best-corrected visual acuity (BCVA), size of choroidal neovascularization, and the presence of hemorrhage and exudate were analyzed and the association between BCVA change and ...
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Authors: Curtin K, Theilen LH, Fraser A, Smith KR, Varner MW, Hageman GS Abstract BACKGROUND: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD). METHODS: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Risk of CNV AMD was estimated using Cox models. FINDINGS: Women with HDP exhibite...
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
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