Use it or lose it to age: A review of bone and muscle communication

Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism. A relatively new concept is that muscle, especially contracted muscle, acts as a secretory organ, regulating metabolism. An even newer concept is that bone, especially the osteocytes in bone, act as endocrine cells targeting other organs such as kidney and more recently, muscle. These two new concepts logically led to the third concept: that muscle and bone communicate via soluble factors.

Source: Bone - November 5, 2018 Category: Orthopaedics Authors: Lynda Bonewald Tags: Full Length Article Source Type: research