Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder

Major depressive disorder (MDD) is one of the most prevalent and disabling psychiatric illness, with a high lifetime prevalence ranging from 10-15% (Kessler et al., 2005, 2013a). Cognitive dysfunction is a core diagnostic feature of MDD and is likely to cause considerable interference and functional impairment in patients' daily life function (Mcintyre et al., 2013), but effective alleviation of the cognitive deficits is difficult to achieve with current antidepressant therapies (Amado-Boccara et al., 1995).

Source: Psychoneuroendocrinology - November 2, 2018 Category: Psychiatry Authors: Yanling Zhou, Wei Zheng, Weijian Liu, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Yuping Ning Source Type: research