Chemical constituents from the branches of Alangium barbatum and their anti-inflammatory activities

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Yang-Guo Xie, Sheng-lan Zhu, Ying-ying Huang, Yi-gong Guo, Guo-jing Wu, Ishaq Muhammad, Shi-kai Yan, Hui-zi Jin, Wei-dong ZhangAbstractTwo new sesquiterpenes (1 and 2), one new alkaloid (4), one new neolignan glycoside (14), together with 19 known compounds were isolated from the branches of Alangium barbatum. Their structures were established by spectroscopic analysis. The absolute configuration of 21 was determined for the first time by single-crystal X-ray diffraction analysis with Cu-Kα irradiation. Some of isolates were evaluated for their inhibitory effects on NO production in LPS-induced RAW264.7 macrophages. Compounds 1, 3 and 9 at 10 μM concentrations exhibited mild inhibitory effects on NO production in the range of 25.0 to 32.4. Moreover, these compounds at 25 μM concentration were also found to mildly suppress NF-κB activation in TNF-α induced expression of NF-κB-Luc in Hela cells with inhibition percent in the range of 15.0 to 25.0%.Graphical abstract

Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research