Four new flavonoids with DGAT inhibitory activity from Psoralea corylifolia

Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Hao-Ze Li, Xiao Meng, Yi-Yu Jiang, Xin Lin, Da-Xi Xiong, Dong Wang, Hyun-Sun Lee, Long CuiAbstractFour new compounds, 3′'-methoxy-bavacoumestan C (1), 6,7-furanbavachinone B (2), 3,4- furanbavachalcone A (3) and 4,5- furanbavachalcone A (4), together with seven known flavonoids were isolated from the Psoralea corylifolia. Their structures were determined by extensive spectroscopic and physicochemical analyses. All the compounds (1–11) were evaluated for in vitro inhibitory activity against DGAT. Among them, compounds 1, 6, 7, 10 and 11 were found to exhibit selective inhibitory activity on DGAT1with IC50 values ranging from 78.5 ± 1.7 to 153.4 ± 1.5 μM.Graphical abstract

Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research