One young person in England is told they have an STI every FOUR MINUTES

Fifteen people aged between 15 and 24 were told they had chlamydia or gonorrhoea every hour in England from 2016-to-2017. Untreated, these can cause everything from infertility and arthritis.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Wonder if I could get some coding wizards to assist - just looking for most RVU 14 yo pt comes in with mom, dad, step mom. Pt spends alternating weeks with mom and then dad. Been having worsening messages from dad who has never come to a clinic visit. Recent was essentially, what the F are you doing putting my son on Risperdal; it causes infertility? Mom has new step son that was in that same day and told her about continued issues with dad's messages. I am reaching the point where... CPT coding assistance
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
Conclusion(s)From a reproductive point of view, there does not seem to be any reason to recommend the increase or the decrease in general physical activity in males from infertile couples. However, additional studies are needed to investigate the relationship between weightlifting and sperm quality.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
We report a 36-year-old man with chronic cough, hemoptysis, significant weight loss, and orogenital ulcers from one year before referral. Initial assessments revealed multiple parahillar nodules in chest X-ray, chronic inflammatory anemia, erythrocyte sedimentation rate more than 100, and positive Human Leukocyte Antigen B5 and B51. Evaluation for infection and malignancies was unremarkable. Open exploratory lung study showed multiple pulsatile nodules in both lungs. AMIGO computed tomogram confirmed multiple right and left pulmonary artery aneurysms and impending to rupture aneurysm at subdivision of inferior mesenteric a...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
This study aims to address whether specific miRNAs in CD14+ monocytes and osteoclasts derived from them cause active osteoclastogenesis in PsA. The RNA from circulatory CD14+ monocytes was isolated from PsA patients, psoriatic patients without arthritis, and normal controls (NCs).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
The requirement for IL-23 in IL-17A and IL-17F production in humans is incompletely understood. Preclinical data support IL-17F, together with IL-17A, as a key driver of chronic tissue inflammation.1 Dysregulation in the frequency and function of MAIT cells, an innate-like T cell population, has been associated with IL-17A-mediated inflammatory diseases, including psoriasis and psoriatic arthritis.2,3 However, IL-17F production by MAIT cells remains largely unexplored. Optimal MAIT cell IL-17A and IL-17F production occurred upon T cell receptor triggering with IL-12 and IL-18, independently of IL-23, as shown by MR1-presen...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
We recently demonstrated that persistent release of IL-1ab from inflammatory skin causes weight loss, vascular sclerotic changes, and severe systemic amyloidosis in multiple organs. We addressed this question by using skin inflammatory mouse model, keratin-14 driven caspase-1 transgenic mice (KCASP1Tg). In inflammatory diseases such as rheumatoid arthritis, secondary intestinal amyloidosis occurs which causes malabsorption and bowel movement obstruction. Also in KCASP1Tg mice, long-lasting expression of IL-1 β causes gastrointestinal amyloidosis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Introduction: As diet modulates inflammation and may impact inflammatory skin disease, our objectives were to assess the relationships between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD). Methods and Results: We conducted cohort studies among women in the Nurses ’ Health Study II. The empirical dietary inflammatory pattern (EDIP) score was calculated at baseline and every four years; incident psoriasis, PsA, and AD were assessed by validated self-report.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
The recent rise in opioid overdose deaths in the United States has been attributed to an increase in prescriptions written to patients for chronic pain. Patients with psoriasis have higher rates of comorbidities that may make them more likely to receive a prescription for an opioid, including psoriatic arthritis, obesity, anxiety and depression, but little is known about opioid prescribing practices in adults with psoriasis. We performed a cohort study using OptumInSight's electronic health records database to compare the rate of opioid prescriptions written to patients with psoriasis compared to adults without psoriasis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
The gut microbiome plays a critical role in immune development and can impact inflammation in distant organs in rheumatoid arthritis, uveitis and alopecia areata. The potential contributions of the microbiota to psoriasis remains unclear. To test the hypothesis that the microbiota contributes to psoriasiform skin inflammation, we treated KC-Tie2, IL-17C+ and KLK6+ psoriasiform mouse models with a broad-spectrum antibiotic cocktail (ampicillin, neomycin, vancomycin). 5-week old psoriasis mice (n=6-14/grp) were exposed to either regular drinking water or the antibiotic cocktail for ∼ 6 weeks, and then the skin examined.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
We previously reported that neutrophil extracellular traps (NETs) increase the percentage of human Th17 cells in 7-day PBMC cultures, dependent upon CD3/CD28 stimulation and the presence of monocytes. Here we further characterize this response and its dependence upon the D10N variant of Act1 encoded by TRAF3IP2, which is genetically implicated in psoriasis and psoriatic arthritis. We fractionated PBMC into monocyte- and T-cell-enriched populations, then recombined them with or without separation by a Transwell filter.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
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