Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis.

Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis.
Crit Rev Microbiol. 2018 Oct 14;:1-16
Authors: Pombinho R, Sousa S, Cabanes D
Abstract
Innate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial pathogenesis gained importance over recent years. SRs regulate the recruitment of immune cells and control both host inflammatory response and bacterial load. In turn, pathogens have evolved different strategies to overcome immune response, avoid recognition by SRs and exploit them to favor infection. Here, we discuss the most relevant findings regarding the interplay between SRs and pathogens, discussing how these multifunctional proteins recognize a panoply of ligands and act as bacterial phagocytic receptors.
PMID: 30318962 [PubMed - as supplied by publisher]

Source: Critical Reviews in Microbiology - October 14, 2018 Category: Microbiology Authors: Pombinho R, Sousa S, Cabanes D Tags: Crit Rev Microbiol Source Type: research