Genomic Characterization of Carbapenemase-producing Klebsiella pneumoniae with Chromosomally Encoded bla NDM-1.

We report here the K. pneumoniae strains carrying chromosomal bla NDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing bla NDM-1, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3-transposase-mediated homologous recombination resulted in the integration of bla NDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.
PMID: 30323033 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - October 15, 2018 Category: Microbiology Authors: Sakamoto N, Akeda Y, Sugawara Y, Takeuchi D, Motooka D, Yamamoto N, Laolerd W, Santanirand P, Hamada S Tags: Antimicrob Agents Chemother Source Type: research