Activation of 2,4-diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a putative dioxygenase.

Activation of 2,4-diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a putative dioxygenase.
Antimicrob Agents Chemother. 2018 Oct 15;:
Authors: Melief E, Bonnett SA, Zuniga ES, Parish T
Abstract
The diaminoquinazoline series has good potency against Mycobacterium tuberculosis Resistant isolates have mutations in Rv3161c, a putative dioxygenase. We carried out metabolite analysis on wild-type and an Rv3161c mutant strain after exposure to a diaminoquinazoline. The parental compound was found in intracellular extracts from the mutant, but not the wild-type. A metabolite consistent with a mono-hydroxylated form was identified in the wild-type. These data support the hypothesis that Rv3161c metabolizes diaminoquinazolines in M. tuberculosis.
PMID: 30323042 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - October 15, 2018 Category: Microbiology Authors: Melief E, Bonnett SA, Zuniga ES, Parish T Tags: Antimicrob Agents Chemother Source Type: research