Effects of ivermectin and oxantel pamoate on tribendimidine: in vitro and in vivo drug-drug interaction study.

Effects of ivermectin and oxantel pamoate on tribendimidine: in vitro and in vivo drug-drug interaction study. Antimicrob Agents Chemother. 2018 Oct 15;: Authors: Neodo A, Schulz JD, Huwyler J, Keiser J Abstract Soil-transmitted helminth (STH) infections still remain a major health problem in poor rural settings. The lack of efficacious drugs against all STH species raises the interest in drug combinations. Drug-drug interactions are, however, of major concern so that careful in vitro and in vivo characterization is needed. The combination of tribendimidine with either ivermectin or oxantel pamoate targets a broad range of STH and thus, represents a promising treatment alternative. Drug-drug interactions, however, have not yet been investigated. Therefore, the effect of combinations of ivermectin, oxantel pamoate and tribendimidine's active metabolite deacylated amidantel (dADT) on the CYP450 metabolism was evaluated followed by a pharmacokinetic analysis of tribendimidine and ivermectin alone and in combination in healthy rats. Oxantel pamoate is only poorly absorbed and was therefore excluded from pharmacokinetic analysis. No evident effect was observed for tribendimidine-oxantel pamoate at CYP450 metabolism level, whereas a combination of tribendimidine and ivermectin led to a moderately increased CYP2D6 inhibition as compared to ivermectin or tribendimidine alone. Co-administration of tribendimidine with ivermectin altered neithe...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research