Ready-to-use 177 Lu-Rituximab injection for Non-Hodgkin ’s Lymphoma: Formulation and preliminary clinical study

This study was aimed at the preparation of177Lu-CHX-A ″-DTPA-Rituximab injection at the hospital pharmacy for non-Hodgkin lymphoma. Rituximab was conjugated with CHX-A″-DTPA-NCS and the CHX-A″-DTPA-Rituximab conjugate was radiolabeled with177Lu in  >  95% purity. The product exhibited excellent in vitro stability up to 5 days at 37 °C. In vitro cell binding studies in Raji cells confirmed the specificity of177Lu-CHX-A ″-DTPA-Rituximab to CD20 antigen. The radioimmunoconjugate exhibited predominantly hepatobiliary clearance and low bone uptake in Swiss mice. Preliminary clinical studies corroborated the usefulness of177Lu-CHX-A ″-DTPA-Rituximab for therapy of non-Hodgkin lymphoma.
Source: Journal of Radioanalytical and Nuclear Chemistry - Category: Nuclear Medicine Source Type: research