Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells by its dNTP triphosphorylase activity t...

Source: Retrovirology - October 13, 2018 Category: Virology Authors: Bijan Mahboubi, Christina Gavegnano, Dong-Hyun Kim, Raymond F. Schinazi and Baek Kim Tags: Research Source Type: research