Rh(iii)-Catalyzed ortho-C-(sp2)-H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis.

Rh(iii)-Catalyzed ortho-C-(sp2)-H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis.
Chem Commun (Camb). 2018 Oct 10;:
Authors: Hande AE, Ramesh VB, Prabhu KR
Abstract
Rh(iii)-Catalyzed ortho-C-H amidation of ketones and aldehydes under cooperative metal organocatalysis has been utilized for synthesizing various ortho-amidocarbonyl analogs, and the reaction for the aldehyde proceeds at ambient temperature. The aniline derivative 3,5-bis(trifluoromethyl)aniline promotes the amidation reaction via a transient imine directing group. The efficient amidation agent is dioxazolone. The synthetic utility has been demonstrated in the synthesis of quindolinone alkaloids.
PMID: 30302452 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 10, 2018 Category: Chemistry Authors: Hande AE, Ramesh VB, Prabhu KR Tags: Chem Commun (Camb) Source Type: research