Zimbabwe:U.S. Hails Progress in Fight Against Cholera
[The Herald] The United States government believes Zimbabwe has made steady progress in the fight against cholera, which claimed 49 lives, mainly in Harare.
In this study, we investigated the role of CAR in the regulation of cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride transport in T84 human colonic epithelial cells and mouse intestinal tissues. Treatments of T84 cell monolayers with specific CAR agonists (CITCO and phenytoin at concentrations of 1 μM and 5 μM, respectively) for 24 h decreased transepithelial Cl− secretion in response to cAMP-dependent agonist. This inhibition was abolished by coincubation of CITCO with a CAR antagonist, CINPA1. We confirmed that an inhibitory effect of CAR agonists was no...
[Monitor] Kampala -The Cholera outbreak has spread to other parts of Kampala City as Naguru hospital continues to receive suspected cholera patients.
[Monitor] In the wake of the current cholera outbreak in the outskirts of Kampala City, National Water and Sewerage Corporation (NWSC), is taking a positive step to address the problem.
Source: Solidarites International. Published: 3/2018. The aim of this 116-page operational manual is to help missions improve their water, sanitation, and hygiene (WASH) response strategies in the context of recurrent cholera outbreaks. It contains key elements to guide teams in setting up cholera epidemic response and disease prevention programs in endemo-epidemic areas. Its three parts cover general information on cholera, before and between epidemics, and response to cholera epidemics. (PDF)
Abstract Apart from its function as a redox cofactor, nicotinamide adenine dinucleotide (NAD+) is a crucial substrate for NAD+-consuming enzymes, including PARPs. Their association with severe diseases necessitates the development of new discovery and analytical tools based on traceable NAD+ surrogates. Here we describe the synthesis, photophysics and biochemical utilization of an emissive, thieno[3,4-d]pyrimidine-based, NAD+ surrogate, termed NthAD+. It is enzymatically prepared from synthetic thATP via nicotinamide mononucleotide adenylyltransferase 1. NthAD+ displays useful photophysical features including red-...
[New Zimbabwe] Ministry of health officials in Murewa have for the second time in less than a month called in the police to shut down a popular Johanne Marange apostolic sect shrine in the area following the death of four members, including the sect leader, from cholera.
Abstract Pasteurella multocida (P. multocida), a causative agent of fowl cholera, is an important pathogen in the poultry industry. In the present study, we found that the inactivated vaccine of P. multocida grown in an iron-restricted medium provided better protection than that grown in normal medium. Thus, we adopted a comparative proteomics approach, by using two-dimensional gel electrophoresis (2-DE), coupled with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/TOF MS), to profile the supernatant proteins associated with P. multocida under both conditions. Eleven upregul...
[New Zimbabwe] Zimbabwe has recorded the highest number of cholera-related cases and deaths in the Eastern and Southern Region (ESAR) with 65 deaths and over 10 000 cases reported in the last quarter of 2018.
[Independent (Kampala)] Kampala -Health workers at Naguru Hospital have been warned against extorting money from Cholera patients.
[The Herald] Government has disbursed about $240 000 to the Midlands Civil Protection Unit to combat cholera in Mberengwa following the outbreak of the water-borne disease in Chomubobo resettlement areas. The disease has since claimed two lives from the 26 cases reported since its outbreak on December 18 last year.