Terrien Marginal Degeneration

Terrien marginal degeneration (TMD), a rare disease resulting in peripheral corneal thinning, commonly occurs in middle aged males and usually manifests clinically with decreased visual acuity from increased corneal astigmatism. Although the exact etiology is unknown, hypotheses focus on possible degenerative and inflammatory origin. Histopathologic studies often reveal characteristic findings of innumerable intracellular and extracellular vacuoles in the affected stroma. Distinguishing TMD from other peripheral corneal diseases such as Mooren ulcer and pellucid marginal degeneration is important.

Source: Survey of Ophthalmology - October 11, 2018 Category: Opthalmology Authors: Yanning Ding, Michael S. Murri, Orry C. Birdsong, Yasmyne Ronquillo, Majid Moshirfar Tags: Major review Source Type: research