A Ligand Enabled Palladium Catalyzed Highly para-Selective Difluoromethylation of Aromatic Ketones.

A Ligand Enabled Palladium Catalyzed Highly para-Selective Difluoromethylation of Aromatic Ketones.
Angew Chem Int Ed Engl. 2018 Oct 09;:
Authors: Tu G, Yuan C, Li Y, Zhang J, Zhao Y
Abstract
A practical and highly para-selective C-H difluoromethylation of aromatic ketones has been developed by employing tetrakis(triphenylphosphine)palladium(0) as the catalyst and triphenylphosphine as the ligand. In addition to general aromatic ketones, this transformation was compatible with bioactive compounds and well-known drugs, such as oxybenzone, ketoprofen, zaltoprofen, and propafenone. Moreover, the mechanistic study revealed that the palladium complex coordinated with the carbonyl group to affect the highly para-selective difluoromethylation reaction.
PMID: 30299562 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - October 9, 2018 Category: Chemistry Authors: Tu G, Yuan C, Li Y, Zhang J, Zhao Y Tags: Angew Chem Int Ed Engl Source Type: research