Effects of Methylphenidate During Fear Learning in Antisocial Adolescents: A Randomized Controlled fMRI Trial
Although the neural underpinnings of antisocial behavior have been studied extensively, research on pharmacologic interventions targeting specific neural mechanisms remains sparse. Hypoactivity of the amygdala and ventromedial prefrontal cortex (vmPFC) has been reported in antisocial adolescents, which could account for deficits in fear learning (amygdala) and impairments in decision making (vmPFC), respectively. Limited clinical research suggests positive effects of methylphenidate, a dopamine agonist, on antisocial behavior in adolescents.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Koen van Lith, Dick Johan Veltman, Moran Daniel Cohn, Louise Else Pape, Marieke Eleonora van den Akker-Nijdam, Amanda Wilhelmina Geertruida van Loon, Pierre Maria Bet, Guido Alexander van Wingen, Wim van den Brink, Theodorus Adrianus Henricus Doreleijers, Tags: New research Source Type: research
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