In proteins, the structural responses of a position to mutation rely on the Goldilocks principle: not too many links, not too few

Phys. Chem. Chem. Phys., 2018,20,25399-25410 DOI: 10.1039/C8CP04530E, PaperRodrigo Dorantes-Gilardi, La ëtitia Bourgeat, Lorenza Pacini, Laurent Vuillon, Claire Lesieur A disease has distinct genetic and molecular hallmarks such as sequence variants that are likely to produce the alternative protein structures accountable for individual responses to drugs and disease development. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Phys. Chem. Chem. Phys. latest articles - October 10, 2018 Category: Chemistry Authors: Rodrigo Dorantes-Gilardi Source Type: research