An Application of Deep Learning to Detect Process Upset during Pharmaceutical Manufacturing using Passive Acoustic Emissions

Publication date: Available online 22 September 2018Source: International Journal of PharmaceuticsAuthor(s): Allan Carter, Lauren BriensAbstractThe multivariate nature of a fluidized bed system creates process complexity that increases the risk of production upset. This research explores the use of passive acoustic emissions monitoring paired with an artificial neural network to detect fluidized bed distributor plate blockage. In many cases, early process failure detection can allow for immediate intervention, thus lowering operation costs. Blockages were simulated by actively covering portions of a top-spray fluidized bed distributor plate. Piezoelectric microphones were placed within the fluidized bed exhaust and attached externally to the vessel wall. Several time and frequency domain feature vectors were extracted from the monitoring data using the open source pyAudioAnalysis library in Python. Through deep learning, the artificial neural network used these feature vectors to train against each distributor plate blockage condition. The deep learning model was then evaluated using k-fold cross validation. The findings were very positive and successfully demonstrated an application of deep learning to detect process upset.Graphical abstract

Source: International Journal of Pharmaceutics - October 5, 2018 Category: Drugs & Pharmacology Source Type: research