Pushing the limits of detection for proteins secreted from single cells using quantum dots

Analyst, 2018, Advance Article DOI: 10.1039/C8AN01083H, PaperVanessa Herrera, Ssu-Chieh Joseph Hsu, Maha K. Rahim, Carol Chen, Lisa Nguyen, Wendy F. Liu, Jered B. Haun Single cell secretion studies have provided valuable insight into population heterogeneity, but low detection sensitivity requires cells to secrete thousands of molecules. We employed semiconductor quantum dots and a new single particle imaging approach to improve detection sensitivity to only a few secreted molecules per cell. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Vanessa Herrera Source Type: research