Multidisciplinary therapy for scirrhous gastric cancer: a retrospective analysis and proposal of new treatment strategy

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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AbstractFirst-line chemotherapy for many solid tumors is limited by toxicity. There is a growing interest in maintenance therapy as a strategy for prolonging the benefits of first-line therapy while minimizing toxicity. Maintenance therapy can comprise either continuation of an agent given as part of the first-line regimen (continuation maintenance) or treatment with a new agent (switch maintenance). Maintenance therapy is already established in several solid tumors, including lung, breast, gastric, colorectal, and ovarian cancer. Immune checkpoint inhibitor treatment has been shown to prolong duration of response and over...
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
The article Trifluridine/Tipiracil: A Review in Metastatic Gastric Cancer, written by Connie Kang, Sohita Dhillon and Emma D. Deeks, was originally published Online First without open access
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionmiR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Kun Zhou, Huan Guo, Jun Zhang, Dongmei Zhao, Yuzhen Zhou, Zunrong Zheng, Yuhong Xu, Yanli Li, Donghua WangAbstractGastric cancer (GC) represents one of the most predominant malignancies with high incidence and mortality rates. Although traditional chemotherapeutics, including cisplatin are effective in the treatment of GC, patients often develop drug resistance in clinic. The present study aimed to explore the underlying mechanism of cisplatin-induced drug resistance in GC. The potential role of DNA demethylase ten-eleve...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Ha Yoon Mo, Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Chang Hyeok An, Sug Hyung Lee
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study is aimed at assessing the antimicrobial activity of aqueous extract obtained from Quercus brantii var. persica seed coat (Testa) on H. pylori isolated from gastric biopsy specimens.MethodsSuch specimens were collected from 100 patients presenting with endoscopic gastroduodenal findings. Testa extracts were prepared from Persian Oak forests in the province of Kohgiluyeh and Boyer-Ahmad, IRAN. H. pylori isolates were obtained by a series of standard bacteriology tests and cell culture, then were confirmed by PCR. The activity of testa extracts towards 25 H. pylori isolates was assessed by well diffusion method, mi...
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
We examined incidence, mortality and survival over three decades in a large population-based registry study.MethodsThis retrospective study included all cases (n = 4580) of NETs diagnosed from 1986 to 2015 in Queensland, Australia. We examined directly age-standardised incidence and mortality rates. The impact on overall survival according to demographic factors and primary site was modelled using multivariable Cox proportional hazards regression (HR). Cause-specific and relative survival were estimated using the Kaplan-Meier survival function.ResultsAnnual incidence increased from 2.0 in 1986 to 6.3 per 100,...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Authors: Demiryas S, Kocazeybek B, Demirci M, Caliskan R, Kepil N, Uysal HK, Dinc HO, Saribas S, Ergin S, Erzin Y, Tasci İ, Erdamar S, Demirdag C, Tokman HB Abstract Helicobacter pylori (H. pylori) is involved in the etiology of gastric cancer (GC). miRNAs are short RNAs that regulate gene expression by marking mRNAs for degradation. miRNAs are involved in tumorigenesis, metastasis, and cell proliferation. We aimed to investigate the miRNA expression profiles of tissues from H. pylori (+) and (-) GC patients. Forty GC patients, 20 H. pylori (+) and 20 H. pylori (-), and a healthy control group were included. The m...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
In conclusion, these results indicated that lncRNA‑MEG3 may regulate EMT‑associated signaling pathways and has the potential as a therapeutic target in gastric carcinoma. PMID: 31524253 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, overexpression of Linc‑pint may inhibit the growth of gastric tumors via downregulation of HIF‑1α. PMID: 31524232 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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