GSE115623 Genome-wide fork-collapse sites in MDA-MB-231 cells from ATR inhibition [human]

Contributors : Nishita K Shastri ; Eric J BrownSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTransient obstruction of DNA polymerase progression activates the ATR checkpoint kinase, which suppresses fork breakage, strand resection, and RPA accumulation. Herein, we use a developed DNA break-detection assay, BrITL, to identify replication-problematic loci that become processed into persistent double-strand breaks across the human genome from ATR inhibition.

Source: GEO: Gene Expression Omnibus - October 4, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research