Decarboxylative Negishi Coupling of Redox-Active Aliphatic Esters by Cobalt Catalysis.

Decarboxylative Negishi Coupling of Redox-Active Aliphatic Esters by Cobalt Catalysis.
Angew Chem Int Ed Engl. 2018 Oct 01;57(40):13096-13100
Authors: Liu XG, Zhou CJ, Lin E, Han XL, Zhang SS, Li Q, Wang H
Abstract
A cobalt-catalyzed decarboxylative Negishi coupling reaction of redox-active aliphatic esters with organozinc reagents was developed. The method enabled efficient alkyl-aryl, alkyl-alkenyl, and alkyl-alkynyl coupling reactions under mild reaction conditions with no external ligand or additive needed. The success of an in situ activation protocol and the facile synthesis of the drug molecule (±)-preclamol highlight the synthetic potential of this method. Mechanistic studies indicated that a radical mechanism is involved.
PMID: 30252190 [PubMed - in process]

Source: Angewandte Chemie - September 28, 2018 Category: Chemistry Authors: Liu XG, Zhou CJ, Lin E, Han XL, Zhang SS, Li Q, Wang H Tags: Angew Chem Int Ed Engl Source Type: research