Intermolecular Allylic C-H Etherification of Internal Olefins.

Intermolecular Allylic C-H Etherification of Internal Olefins.
Angew Chem Int Ed Engl. 2018 Sep 26;:
Authors: Nelson T, Blakey SB
Abstract
Herein we report on the development of an oxidative allylic C-H etherification reaction, utilizing internal olefins and alcohols as simple precursors. Key advances include the use of RhCp* complexes to promote the allylic C-H functionalization of internal olefins and the compatibility of the oxidative conditions with oxidatively sensitive alcohols, enabling the direct etherification reaction. Preliminary mechanistic studies, consistent with C-H functionalization as the rate determining step, are presented.
PMID: 30256503 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - September 26, 2018 Category: Chemistry Authors: Nelson T, Blakey SB Tags: Angew Chem Int Ed Engl Source Type: research