Redox alteration in patients infected by different HCV genotypes.

Redox alteration in patients infected by different HCV genotypes. Infez Med. 2018 Sep 01;26(3):249-254 Authors: Limongi D, Baldelli S, Santi F, D'Agostini C, Palamara AT, Nencioni L, Ciotti M Abstract Chronic hepatitis C virus (HCV) infection plays a pivotal role in hepatocarcinogenesis and has been associated with oxidative DNA damage. Few data have been reported on the general redox state in patients infected with different HCV genotypes. Total antioxidant capacity (TAC) and hydrogen peroxide levels as well as oxidative stress index were measured in serum of hepatitis C chronic patients in relation to genotype, viral load, transaminases level and degree of fibrosis. Serum was obtained from two-hundred-fifty-two HCV infected patients and twenty-five healthy donors. TAC was measured by TAC Colorimetric Assay and hydrogen peroxide concentration by Hydrogen Peroxide Colorimetric Assay Kit. In HCV infected patients, mean serum TAC was 5.62 mM Trolox equivalents which was significantly lower (p < 0.0001) than control group (7.25 mM Trolox equivalents). TAC reduction was particularly evident in patients infected by genotype 2 compared to those infected by genotypes 1, 3 and 4. In parallel, high levels of hydrogen peroxide were found in the serum of infected patients, p=0.0015. Although no statistically significant correlation was found with the degree of fibrosis, transaminases level or viral load, oxidative stress index was higher in ...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research