Electron microscopy of urinary sediments in Fabry  disease

A 60-year-old woman on peritoneal dialysis was found to have fatty bodies with whorl-like structures (called Mulberry bodies) in her urine, suggesting Fabry disease. Fabry disease is an X-linked hereditary disease, and  the phenotypes of female patients are often mild with a normal range of α-galactosidase activity. Her plasma globotriaosylceramide was increased, but renal biopsy samples showed a few ceramide deposits in the glomerular podocytes, renal tubular cells, and interstitial macrophages.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research