A Multistep Algorithm to Detect In Situ Melanomas A Multistep Algorithm to Detect In Situ Melanomas

The authors present a multistep diagnostic algorithm for in situ melanoma detection using reflectance confocal microscopy combined with dermoscopy.The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

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Conclusion: Our studies suggested sequencing even a single, frequently mutated gene may provide insight into genome-wide mutational burden, and may serve as a biomarker to predict immune response.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conditions:   Metastatic Melanoma;   Metastatic Malignant Neoplasm in the Chest Wall;   Recurrent Breast Carcinoma Interventions:   Drug: Olaparib;   Procedure: Hyperthermia Treatment;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment Sponsors:   Thomas Jefferson University;   AstraZeneca Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Melanoma Interventions:   Drug: SHR1210;   Drug: apatinib mesylate Sponsor:   Beijing Cancer Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The National Cancer Institute has opened a clinical trial using mesothelioma patients and their family members to explore predisposition to the cancer and potential solutions to negating it. The trial is a follow up to an earlier study of a genetic mutation that creates susceptibility to various cancers but a longer-than-normal survival with platinum-based chemotherapy treatment. “This is an important, long-term study that could have implications not only for a patient, but for family members, too,” Dr. Raffit Hassan, NCI senior investigator told The Mesothelioma Center at Asbestos.com. “Progress can be m...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
AbstractThe significance of pattern recognition techniques is widely enhanced in image processing and medical applications. Thus, lesion segmentation method is an essential technique of pattern recognition algorithms to detect the melanoma skin cancer in patients at earliest stage, otherwise, in further stages it becomes one of the deadliest disease and its mortality rate is very high. Therefore, a precise melanoma segmentation technique is introduced based on the Gradient and Feature Adaptive Contour (GFAC) model to detect melanoma skin cancer in earliest stage and diagnosis ofdermoscopic images. In the proposed image seg...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Nature Reviews Clinical Oncology, Published online: 20 May 2019; doi:10.1038/s41571-019-0230-4My husband’s diagnosis with melanoma and our struggle to access effective therapy challenged what I had learnt about medical research. I have since founded a patient network, becoming a vocal advocate for patient-centric drug development. Herein, I discuss some of the lessons I have learnt.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research
AbstractCancer cells can escape the immune system by different mechanisms. The evasion of cancer cells from immune surveillance is prevented by immune checkpoint inhibitors, allowing the patient ’s own immune system to attack their cancer. Immune checkpoint inhibitors have shown improvement in overall survival for melanoma, lung cancer and renal cell carcinoma in clinical trials. Unfortunately, not all patients respond to this therapy.In cancer management, percutaneous ablation techniques are well established for both cure and local control of many tumour types. Cryoablation of the tumour tissue results in cell destr...
Source: Insights into Imaging - Category: Radiology Source Type: research
Authors: Becquart O, Guillot B, Bourrain JL, Duflos C, Du-Thanh A Abstract The risk of skin cancer induced by photosensiting drugs is well known. An association between hydrochlorothiazide use and skin cancer has been recently published in some epidemiological studies. A systematic review of case-control or prospectives cohorts showed an increased risk of cutaneous squamous cell carcinoma even if some confusing factors such as tobacco smoking was not analysed. Results are more conflicting for basal cell carcinoma or melanoma. These results do not modify the benefit/risk ratio but should lead to propose preventive m...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Authors: Zibelman M, Olszanski AJ Abstract Metastatic melanoma is a devastating disease that has been increasing in incidence and until relatively recently had few effective treatment options. With the approval in 2011 of ipilimumab, a monoclonal antibody against cytotoxic T-lymphocyte associated protein 4 (CTLA-4), however, that has begun to change. Ipilimumab is an immune checkpoint inhibitor, a type of immunotherapy that can down-regulate inhibitory signals affecting T-cell activation to unleash more dramatic anti-tumoral responses and offer the possibility of deep and durable remissions in up to 20% of patients...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Paolo Perri Uveal melanoma (UM), which is the most common cancer of the eye, was investigated in recent years by many teams in the field of biomedical sciences and eye clinicians. New knowledge was acquired on molecular pathways found to be dysregulated during the multistep process of oncogenesis, whereas novel therapeutic approaches gave significant results in the clinical applications. Uveal melanoma-affected patients greatly benefited from recent advances of the research in this eye cancer. Tumour biology, genetics, epigenetics and immunology contributed significantly in elucidating the role of different genes and r...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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