Integrin and microtubule crosstalk in the regulation of cellular processes.

Integrin and microtubule crosstalk in the regulation of cellular processes.
Cell Mol Life Sci. 2018 Sep 11;:
Authors: LaFlamme SE, Mathew-Steiner S, Singh N, Colello-Borges D, Nieves B
Abstract
Integrins engage components of the extracellular matrix, and in collaboration with other receptors, regulate signaling cascades that impact cell behavior in part by modulating the cell's cytoskeleton. Integrins have long been known to function together with the actin cytoskeleton to promote cell adhesion, migration, and invasion, and with the intermediate filament cytoskeleton to mediate the strong adhesion needed for the maintenance and integrity of epithelial tissues. Recent studies have shed light on the crosstalk between integrin and the microtubule cytoskeleton. Integrins promote microtubule nucleation, growth, and stabilization at the cell cortex, whereas microtubules regulate integrin activity and remodeling of adhesion sites. Integrin-dependent stabilization of microtubules at the cell cortex is critical to the establishment of apical-basal polarity required for the formation of epithelial tissues. During cell migration, integrin-dependent microtubule stabilization contributes to front-rear polarity, whereas microtubules promote the turnover of integrin-mediated adhesions. This review focuses on this interdependent relationship and its impact on cell behavior and function.
PMID: 30206641 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - September 11, 2018 Category: Cytology Authors: LaFlamme SE, Mathew-Steiner S, Singh N, Colello-Borges D, Nieves B Tags: Cell Mol Life Sci Source Type: research