Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma.

Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma.
Transl Oncol. 2018 Sep 06;11(6):1350-1357
Authors: Desantis V, Saltarella I, Lamanuzzi A, Mariggiò MA, Racanelli V, Vacca A, Frassanito MA
Abstract
Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. In physiological condition, autophagy funnels cytoplasmic constituents to autophagolysosomes for degradation and is an alternative way for cell-death behavior. Here, we inspected autophagy as a prosurvival mechanism essential for drug resistance in multiple myeloma (MM). Accordingly, autophagy inhibitors used in association to conventional anti-MM drugs might enforce the effect against resistant MM plasma cells and render autophagy a new therapeutic target.
PMID: 30196237 [PubMed - as supplied by publisher]

Source: Translational Oncology - September 6, 2018 Category: Cancer & Oncology Authors: Desantis V, Saltarella I, Lamanuzzi A, Mariggiò MA, Racanelli V, Vacca A, Frassanito MA Tags: Transl Oncol Source Type: research