GSE110669 Transcriptional profiles of normal human mature B cells

Contributors : Katia Basso ; Antony Baden Holmes ; Riccardo Dalla-FaveraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMature B cells leave the bone marrow as na ïve B cells and migrate to the secondary lymphoid organs where they encounter the antigen for the first time. This interaction stimulates B cells to rapidly grow and form characteristic histological structures called germinal center. In the germinal centers, B cells are targeted by mechanisms of ge netic editing of the immunoglobulin loci, namely somatic hypermutation and class switch recombination, undergo selection for high affinity immunoglobulin receptors and are committed to differentiate into memory B cells or plasma cells. GCs display two histological areas the dark and the light zone t hat have been characterized as functionally distinct compartments through which B cells recycle multiple times during the germinal center reaction.

Source: GEO: Gene Expression Omnibus - September 10, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research