Ancient thunder god vine could hold the cure to the obesity epidemic

Scientists from the German Center for Diabetes Research found that when the herbal extract celastrol is fed to obese mice, the rodents eat less, which causes them to shed the pounds.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Clin Ther. 2022 Jan 22:S0149-2918(22)00004-2. doi: 10.1016/j.clinthera.2021.12.011. Online ahead of print.ABSTRACTPURPOSE: The incidence of hepatocellular carcinoma (HCC) in the United Kingdom has increased 60% in the past 10 years. The epidemics of obesity and type 2 diabetes are contributing factors. In this article, we examine the impact of diabetes and glucose-lowering treatments on HCC incidence and overall survival (OS).METHODS: Data from 1064 patients diagnosed with chronic liver disease (CLD) (n = 340) or HCC (n = 724) were collected from 2007 to 2012. Patients with HCC were followed up prospectively. Univariate an...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Source Type: research
Trends Endocrinol Metab. 2022 Jan 22:S1043-2760(21)00300-3. doi: 10.1016/j.tem.2021.12.005. Online ahead of print.ABSTRACTPoor nutrition, lack of exercise, and genetic predisposition all contribute to the growing epidemic of obesity. Overweight/obesity create an environment of chronic inflammation that leads to negative physiological and neurological outcomes, such as diabetes, cardiovascular disease, and anxiety/depression. While the whole body contributes to metabolic homeostasis, the neuroimmune system has recently emerged as a key regulator of metabolism. Microglia, the resident immune cells of the brain, respond both ...
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research
Nutrients. 2022 Jan 13;14(2):319. doi: 10.3390/nu14020319.ABSTRACT(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance of trace elements in the body caused by nutritional factors can lead to the progression of coronary atherosclerosis. (2) Methods: We measured the concentrations of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), and iron (Fe) in peripheral blood samples from 4243 patients and performed baseline analysis and propensity matching of the patie...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
At present, the worldwide prevalence of obesity has become alarmingly high with estimates foreshadowing a continued escalation in the future. Furthermore, there is growing evidence attributing an individual’s predisposition for developing obesity to maternal health during gestation. Currently, 60% of pregnancies in the US are to either overweight or obese mothers which in turn contributes to the persistent rise in obesity rates. While obesity itself is problematic, it conveys an increased risk for several diseases such as diabetes, inflammatory disorders, cancer and cardiovascular disease (CVD). Additionally, as we a...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Inflamm Regen. 2022 Jan 19;42(1):5. doi: 10.1186/s41232-021-00189-0.ABSTRACTThe global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of these metabolic diseases, indicating that immune responses are closely involved in the pathogenesis of metabolic disorders. However, the regulatory mechanisms underlying immunometabolic crosstalk in these diseases are not completely understood. Recent studies have revealed the multifaceted functions of semaphorins, originally identified as axon...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
The number of people with type 2 diabetes continues to increase in New Zealand (NZ), due to the obesity epidemic, population growth, increases in ethnic diversity and life expectancy [1,2]. The prevalence of type 2 diabetes in NZ is highest for Pacific (13.6%) compared with M āori (7.9%), Asian (6.2 %) and European (4.9%) populations [3].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Diabetes Mellitus is considered a public health problem and a large epidemic challenge. Type 2 diabetes (T2D) is the most frequent form of diabetes and it is estimated that by 2045 the number of diabetics will be 629 million worldwide [1]. Type 2 diabetes (T2D) prevalence has increased partially due to the aging of the population as well as the dramatic increase in obesity. In the National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2014, the prevalence of T2D in subjects of ≥65 years old increased from 18.4 to 24.7%, while in the younger population it increased from 8.8 to 11.0% [2].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Endocr Rev. 2022 Jan 18:bnac003. doi: 10.1210/endrev/bnac003. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) traditionally refers to abnormal glucose tolerance with onset or first recognition during pregnancy (1). GDM has long been associated with obstetric and neonatal complications primarily relating to higher infant birthweight and is increasingly recognised as a risk factor for future maternal and offspring cardiometabolic disease. The prevalence of GDM continues to rise internationally due to epidemiological factors including the increase in background rates of obesity in women of reproductive age a...
Source: Endocrine Reviews - Category: Endocrinology Authors: Source Type: research
Mol Cell Biochem. 2022 Jan 13. doi: 10.1007/s11010-021-04324-w. Online ahead of print.ABSTRACTObesity is a complex epidemic disease caused by an imbalance of adipose tissue function that results in hyperglycemia, hyperlipidemia and insulin resistance which further develop into type 2 diabetes, cardiovascular disease and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Adipose tissue is responsible for fat storage; white adipose tissue stores excess energy as fat for availability during starvation, whereas brown adipose tissue regulates thermogenesis through fat oxidation using uncoupling protein 1. However, h...
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research
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