Sma clinical data, outcome measures and registries

We aim to evaluate the pattern of bone mass acquisition and fracture determinants in type 2/3 patients. DXA measurements of total body less head bone mineral density (TB-BMD and Z-score), bone mineral content (TB-BMC), fat mass (FM) and fat free mass (FFM) were obtained in 19 subjects with SMA (10 SMA2, 9 SMA3) and 19 controls, at baseline and every 12 months for 36 months. At baseline, the median age was 9.4 years. All patients underwent anthropometric (HT SDS, BMI SDS) and biochemical bone turnover evaluations.

Source: Neuromuscular Disorders - September 6, 2018 Category: Neurology Authors: N. DiIorgi, E. Medone, G. Brigati, S. Notarnicola, C. Panicucci, C. Fiorillo, M. Pedemonte, C. Minetti, M. Maghnie, C. Bruno Source Type: research