Chemodiversity of Clausena excavata (Rutaceae) and related species: Coumarins and carbazoles

Publication date: October 2018Source: Biochemical Systematics and Ecology, Volume 80Author(s): Natthawadi Wongthet, Nuttha Sanevas, Johann Schinnerl, Karin Valant-Vetschera, Markus Bacher, Srunya VajrodayaAbstractMethanolic crude extracts obtained from leaves, stem bark and root bark of 57 accessions of Clausena excavata, C. harmandiana, of both varieties of C. wallichii, as well as of three unidentified Clausena samples, were analysed for the presence of coumarins and carbazoles. All accessions were collected from different locations all over Thailand. HPLC coupled with UV-DAD was applied for phytochemical profiling. Structures of known pyrano-coumarins 1–4 and of coumarins 5–8 bearing an O-geranyl moiety, as well as of carbazoles 9–12 were confirmed by NMR and MS spectroscopy, respectively. Observed chemical diversification in the studied samples is discussed in relation to geographic distribution and with respect to organ-specific accumulation. Chemotaxonomic significance is briefly addressed.Graphical abstract
Source: Biochemical Systematics and Ecology - Category: Biochemistry Source Type: research